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目的:探讨正肝汤对肝硬化大鼠内分泌激素的影响。方法:大鼠随机分成试验组,造模组,正常对照组;除正常组外,以20%乙醇及猪油颗粒饲料喂养并皮下注射四氯化碳花生油造模,并喂服药物,疗程结束后通过检测胰高血糖素(GG)、内皮素(ET)观察正肝汤对肝硬化大鼠的内分泌激素影响。结果:治疗组和造模组与正常组在胰高血糖素、内皮素有统计学意义(P<0.01),同时治疗组相对于造模组在胰高血糖素、内皮素上明显改善(P<0.01)。结论:正肝汤能有效改善肝硬化大鼠内分泌激素的紊乱。
Objective: To investigate the effect of Zhenggan decoction on endocrine hormones in rats with cirrhosis. METHODS: Rats were randomly divided into experimental group, model group, and normal control group. In addition to the normal group, 20% ethanol and lard pellets were fed and subcutaneously injected with carbon tetrachloride peanut oil, and the drugs were fed. The treatment was completed. After observing glucagon (GG) and endothelin (ET), the effect of Zhenggan Decoction on the endocrine hormones in cirrhotic rats was observed. RESULTS: The glucagon and endothelin levels in the treatment group and the model group were significantly higher than those in the normal group (P<0.01). At the same time, the treatment group was significantly improved in glucagon and endothelin compared to the model group. <0.01). Conclusion: Zhenggan Decoction can effectively improve the disorder of endocrine hormones in rats with cirrhosis.