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近年庆大霉素引起过敏性休克、皮肤过敏,急性肾功能损害、急性肺水肿、变应性心肌损伤、粒细胞缺乏症及神经系统损害等均有报道,现将3例庆大霉素中毒引起前庭系损害,经随访9~15年,报告如下。病例1 患者,女性,39岁。1978年1月中旬门诊诊断双侧慢性化脓性中耳炎,给予纯庆大霉素滴耳治疗,每侧每次2滴,2次/日,至第7日晚,患者走路不自主向左侧倾斜,次日晨出现恶心、呕吐、眩晕、视物不清、站立不稳等症状,停用庆大霉素。病情继续进展,于第3病日以眩晕原因待查入耳鼻喉科诊治。
In recent years, gentamicin caused anaphylactic shock, skin allergies, acute renal impairment, acute pulmonary edema, allergic myocardial injury, agranulocytosis and nervous system damage have been reported, now 3 cases of gentamicin poisoning Cause Department of vestibular damage, after a follow-up of 9 to 15 years, the report is as follows. Case 1 patient, female, 39 years old. Mid-January 1978 outpatient diagnosis of bilateral chronic suppurative otitis media, given gentamicin ear drops treatment, each side 2 drops each time, 2 times / day, to the evening of the 7th, the patient walking involuntarily leftward tilt , The next morning there nausea, vomiting, dizziness, blurred vision, standing instability and other symptoms, disable gentamicin. The condition continues to progress, due to dizziness on the 3rd day to be admitted to ENT treatment.