氯吡格雷是心血管系统基础用药之一,可用于心肌梗死、缺血性卒中、外周动脉性疾病、急性冠脉综合征的二级预防。由于氯吡格雷研发年份较早,目前研究报道主要集中在临床应用,动物试验药效学较少。但氯吡格雷应用的基础性和广泛性,使其研究方法对其他心血管药物的开发具有极大借鉴意义,所以本文对氯吡格雷动物试验药效学研究进展进行了综述。 Clopidogrel is one of the basic cardiovascular drugs, which can be used for secondary prevention of myocardial infarction, ischemic stroke, peripheral arterial disease and acute coronary syndrome. Due to the earlier research and development of clopidogrel, the current research reports mainly focus on clinical applications, animal experiments less pharmacodynamics. However, the basic and extensive application of clopidogrel makes its research method of great reference for the development of other cardiovascular drugs, so this article reviewed the progress of pharmacodynamic studies of clopidogrel in animal experiments.