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脑卒中是高致残率、高复发率及高死亡率的疾病。脑卒中所带来的家庭经济负担和损失是不容忽视的。脑卒中疾病发病率升高,并成为我国老年人口的首位死亡原因。但是常见的脑卒中危险因素如老龄、高血压、高血脂、糖尿病和吸烟等不能完全解释日益增长的脑卒中复发及死亡率的增加。近年来同型半胱氨酸代谢水平作为脑卒中可控危险因素逐渐受到重视。同型半胱氨酸水平是动脉粥样硬化的危险因素,与脑卒中的复发及预后密切相关。通过治疗降低同型半胱氨酸水平,对降低患者复发率、提高生存质量、减少脑卒中死亡率,对患者回归家庭和社会大有裨益。本文综述了同型半胱氨酸代谢水平与脑卒中复发及预后之间关系的研究进展。
Stroke is a disease of high morbidity, high recurrence and high mortality. The financial burden and loss of families caused by stroke can not be ignored. The incidence of stroke increased and became the first cause of death in China’s elderly population. However, common risk factors for stroke such as aging, hypertension, hyperlipidemia, diabetes and smoking do not fully account for the increased recurrent stroke and increased mortality. Homocysteine metabolism in recent years as a controllable risk factors for stroke gradually attention. Homocysteine is a risk factor for atherosclerosis and is closely related to the recurrence and prognosis of stroke. Through treatment to reduce the level of homocysteine, to reduce the recurrence rate, improve the quality of life, reduce the mortality rate of stroke, the return of patients to families and the community benefit. This article reviews the research progress in the relationship between homocysteine metabolism and stroke recurrence and prognosis.