Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in live

来源 :中国天然药物 | 被引量 : 0次 | 上传用户:yzq660511
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Liver injury remains a significant global health problem and has a variety of causes,including oxidative stress (OS),inflammation,and apoptosis of liver cells.There is currently no curative therapy for this disorder.Sanwei Ganjiang Prescription (SWGJP),derived from traditional Chinese medicine (TCM),has shown its effectiveness in long-term liver damage therapy,although the underlying molecular mechanisms are still not fully understood.To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view,in the present study,a systems pharmacology approach was developed,which involved drug target identification and multilevel data integration analysis.Using a comprehensive systems approach,we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets.We further deciphered the mechanisms of SWGJP in treating liver injury,including compound-target network analysis,target-function network analysis,and integrated pathways analysis.We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway,such as Nrf2-dependent anti-oxidative stress module.Notably,systems pharmacology provides an alternative way to investigate the complex action mode of TCM.
其他文献
Macrophages play an important role in inflammation,and excessive and chronic activation of macrophages leads to systemic inflammatory diseases,such as atherosclerosis and rheumatoid arthritis.In this paper,we explored the anti-inflammatory effect of brous
The raw and processed roots of Plygonum multiflorum Thunb (PM) are used to treat different diseases in clinical practice. In order to clarify the influence of processing, a comparative study of chemical substance analysis was carried out. As the xenobioti
Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum.Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were el
Thibetanosides E-H (1-4),four new steroidal constituents including three rare sulfonates (2-4),were isolated from the roots and rhizomes ofHelleborus thibetanus,together with nine known steroidal compounds (5-13).Their structures were elucidated by detail
The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR;Paeonia Suffruticosa Andrews (Paeoniaceae)] exerts anti-inflammatory,anti-spasmodic,and analgesic effects.In the present study,we investigated the therapeutic effects of differentl
Three new prenylated stilbenes,named as cajanusins A-C (1-3),and one new natural product cajanusin D (4),along with six known derivatives (5-10) were isolated from the leaves of Cajanus cajan.Their structures were fully elucidated by means of extensive sp
Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences, including the weakened immune system. Quercetin is widely distributed bioflavonoid; it has been debated for its dual roles in i
Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata,a key traditional Chinese medicine.The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice.Mice were infected with H1N1 v
Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products.TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy.In this study,we selec
Cangumycins A-F (1-6),six new angucyclinone analogues,together with two known ones (7 and 8),were isolated from the fermentation broth of a soil-derived Streptomyces sp.KIB-M10.Structures of these compounds were elucidated via a joint use of spectroscopic