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目的探讨伴有三系病态造血的初发急性髓样白血病的临床特点、治疗反应及与骨髓增生异常综合征的关系。方法对８８例初发急性髓样白血病治疗前后的骨髓涂片按ＦＡＢ标准判定是否存在三系病态造血，结合临床检验、化疗反应及与骨髓增生异常综合征的关系进行分析。结果８例（９．１％）伴有三系病态造血，见于除急性早幼粒细胞性白血病（Ｍ３）以外的所有ＦＡＢ亚型。这类患者年龄相对较轻，发病时血小板计数正常或明显增高，治疗反应差，治疗后三系病态造血并不消失。结论未发现此类白血病与骨髓增生异常综合征的关系，伴有三系病态造血的急性髓样白血病可能为急性白血病中１个独立临床亚型
Objective To investigate the clinical features, treatment response, and myelodysplastic syndrome in patients with primary acute myeloid leukemia complicated with three-lineage hematopoiesis. Methods Eighty-one bone marrow smears before and after the treatment of acute myeloid leukemia were used to determine whether there was a three-stage pathological hematopoiesis according to FAB criteria. The relationship between clinical tests, chemotherapy response and myelodysplastic syndrome was analyzed. Results Eight patients (9.1%) were associated with a three-line pathological hematopoiesis, which was found in all FAB subtypes except acute promyelocytic leukemia (M3). Such patients are relatively young, with normal or significantly increased platelet counts at the time of onset, and poor response to treatment. Three-stage diseased hematopoiesis does not disappear after treatment. Conclusions No association has been found between this type of leukemia and myelodysplastic syndrome. Acute myeloid leukemia with three series of morbid hematopoiesis may be an independent clinical subtype in acute leukemia.