神经外科手术后的颅内感染是较常见的严重并发症,一直是神经外科发展中难以克服的困难。近年随着抗菌药物的迅速发展,愈来愈多的敏感抗生素应用于腰大池鞘内给药治疗颅内感染,取得了较好的疗效。然而,我们发现对严重的难治性的颅内感染头孢三代抗生素和万古霉素等抗生素难以奏 Intracranial infection after neurosurgery is a more common and serious complication, which has been difficult to overcome in the development of neurosurgery. In recent years, with the rapid development of antimicrobial agents, more and more sensitive antibiotics are applied to intrathecal administration of the lumbar lavage to treat intracranial infections and achieve good therapeutic effects. However, we found it difficult to treat antibiotics such as ceftriaxone and vancomycin against severe refractory intracranial infections