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在着手对哮喘患者进行治疗时,研究并观察患者发作的生物周期(circadium rhythm)是重要的。采用微型最高呼气流速测定仪(如miniwright peak flow meter)定期测定法,发现绝大多数病人的24小时通气功能曲线有1～2个明显的低陷,最常见是在夜间睡醒或凌晨。此时病人常主诉胸闷、气紧。当病人有轻度发作时,此种生物周期则更加明显。有些患者则在数天或几周内呈现通气功能的周期变化。Barnes 认为这种变化可能与内源性肾
It is important to study and observe the circadian rhythm of a patient’s seizure when it comes to treating asthma patients. Using a miniature peak expiratory flow meter (such as the miniwright peak flow meter) routine test found that the vast majority of patients with 24-hour ventilation curve has 1 to 2 obvious subsidence, the most common is the waking or early morning at night. Patients often complain of chest tightness at this time, gas tight. When the patient has a mild attack, the biological cycle is even more pronounced. Some patients exhibit periodic changes in ventilatory function over days or weeks. Barnes believes the change may be related to endogenous kidneys