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研究自体ＬＡＫ细胞回输治疗前后慢乙肝患者门静脉血流动力学。方法应用超声多普勒系统测量１８例经自体ＬＡＫ细胞回输治疗的慢乙肝患者治疗前后门静脉血流动力学参数。结果治疗前门静脉截面积与对照组比较明显增宽（Ｐ＜０．０１），治疗后仍宽于对照组（Ｐ＜０．０１），但比治疗前变窄（Ｐ＜０．０５）。治疗前后血流速度与对照组比较均无显著性差异（Ｐ＞０．０５）。治疗前门静脉血流量明显多于对照组（Ｐ＜０．０１），治疗后与治疗前比较明显减少（Ｐ＜０．０１），与对照组比较无差异（Ｐ＞０．０５）。结论自体ＬＡＫ细胞回输治疗可以改善慢乙肝患者门静脉血流动力学状态。
To study portal hemodynamics in patients with chronic hepatitis B before and after autologous LAK cell transfusion. Methods The portal hemodynamic parameters of 18 patients with chronic hepatitis B treated by autologous LAK cell transfusion were measured by the Doppler ultrasound system before and after treatment. Results The cross-sectional area of portal vein before treatment was significantly wider than that of the control group (P <0.01), but still wider than that of the control group after treatment (P <0.01), but narrower than that before treatment (P <0.05). Before and after treatment, blood flow velocity compared with the control group no significant difference (P> 0.05). The blood flow of portal vein before treatment was significantly more than that of the control group (P <0.01), and after treatment there was a significant decrease (P <0.01) compared with that before treatment. There was no significant difference between the two groups (P> 0.05). Conclusions Autologous LAK cell transfusion therapy can improve portal hemodynamics in chronic hepatitis B patients.