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目的动态了解菌血症患者在治疗前后CD4+/CD8+的变化是否可以判断疗效。方法选择20-59岁发热且血培养阳性的病人为实验组,18-58岁健康体检者作为对照组,外周血CD4+/CD8+检测采用流式细胞仪分析。结果菌血症患者CD4+/CD8+比值明显低于健康对照组,治疗有效后CD4+/CD8+比值逐渐恢复至正常水平,治疗不佳组CD4+/CD8+比值处于低水平。结论动态测定CD4+/CD8+比值可以判断菌血症患者临床治疗的效果。
Objective To understand dynamically whether the change of CD4 + / CD8 + in patients with bacteremia before and after treatment can judge the curative effect. Methods 20-59-year-old fever-positive and blood culture-positive patients were selected as the experimental group and 18-58-year-old healthy subjects as the control group. Peripheral blood CD4 + / CD8 + was detected by flow cytometry. Results The ratio of CD4 + / CD8 + in patients with bacteremia was significantly lower than that in healthy controls. After treatment, the ratio of CD4 + / CD8 + gradually returned to normal level, while the ratio of CD4 + / CD8 + in poorly treated group was low. Conclusion The dynamic determination of CD4 + / CD8 + ratio can be used to determine the clinical efficacy of bacteremic patients.