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目的探讨己酮可可碱治疗大鼠非酒精性脂肪性肝炎的作用。方法68只大鼠随机分为对照组(18只)、模型组(30只)及治疗组(20只),分别于第8周、12周连续4周给予已酮可可碱(PTX)治疗,并在相对应时期进行超声及病理检查,对测量的相关指标进行比较。结果8周模型组肝细胞出现脂肪样变为单纯性脂肪肝,在此基础上12周出现炎性细胞浸润及坏死为中-重度脂肪肝;16周进一步加重,从脂肪性肝炎进展到脂肪性肝纤维化。各组间比较具有显著性差异(P<0.05)。治疗组超声及病理学检查指标均较对照组有明显减轻但无统计学差异。结论己酮可可碱对大鼠非酒精性脂肪性肝炎具有治疗作用。
Objective To investigate the effect of pentoxifylline on non-alcoholic steatohepatitis in rats. Methods Sixty - eight rats were randomly divided into control group (n = 18), model group (n = 30) and treatment group (n = 20). Pentoxifylline (PTX) And in the corresponding period of ultrasound and pathological examination, the measurement of the relevant indicators were compared. Results At the 8th week, the fatty cells in the hepatocytes changed into simple fatty liver. On the basis of these findings, inflammatory cell infiltration and necrosis occurred at 12 weeks in moderate-severe fatty liver, and further increased at 16 weeks. The progression from steatohepatitis to fatty Liver Fibrosis. There was significant difference between the groups (P <0.05). Treatment group ultrasound and pathological examination indicators were significantly reduced compared with the control group but no significant difference. Conclusion Pentoxifylline has a therapeutic effect on nonalcoholic steatohepatitis in rats.