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42名健康人,年龄21～49岁,体重59～106公斤,其中36人分为8组。第七组是葡萄糖—6—磷酸脱氢酶缺乏者。每组有1～2人作为对照,其余的人口服下列药物方案之一:1)每周氯喹300毫克和每天二氨二苯砜25毫克;2)每周氯喹300毫克、伯喹45毫克和每天二氨二苯砜25毫克;3)每周氯喹300毫克和二甲酰二氨基二苯砜400毫克。各组均以感染越南抗氯喹株恶性疟原虫的斯蒂芬按蚊作激发感染1、2或3次。
42 healthy people, aged 21 to 49 years old, weighing 59 to 106 kg, of which 36 were divided into 8 groups. The seventh group is glucose-6-phosphate dehydrogenase deficiency. Each group of 1 to 2 as a control, the remaining oral administration of one of the following programs: 1) weekly chloroquine 300 mg and daily 25 mg of dapsone; 2) weekly chloroquine 300 mg, benzoquin 45 mg and 25 mg of DDT per day; 3) 300 mg of chloroquine per week and 400 mg of dicarboxydiphenylsulfone per week. All groups were challenged 1, 2 or 3 times with Anopheles Stephensi infected with the chloroquine-resistant Plasmodium falciparum in Vietnam.