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从民间抗结核草药紫金牛全草中分得两个新的间苯二酚烯基衍生物,紫金牛酚Ⅰ(1)和紫金牛酚Ⅱ(2)。体外抑制结核菌试验表明,它们为该植物抑制结核杆菌生长的有效成分,经光谱分析与化学降解方法证明,1为2-甲基-5-[8′(顺)-十三烯基]-间苯二酚,2为5-[8′(顺)-十三烯基]-间苯二酚。
Two new resorcinol derivatives, erythrodiol Ⅰ (Ⅰ) and diterpene Ⅱ (2) were isolated from the whole plant of the antimicrobial herb. In vitro inhibition of mycobacterium tuberculosis test showed that they inhibit the growth of the active ingredient of Mycobacterium tuberculosis by spectroscopic analysis and chemical degradation methods to prove that 1 is 2-methyl-5- [8 ’(cis) -tridecenyl] - Resorcinol, 2 is 5- [8 ’(cis) -tridecyl] -resorcinol.