论文部分内容阅读
目的 探讨可溶性细胞间粘附分子 - 1(sICAM - 1)与病毒性肝炎的关系。方法 用ELISA法检测 6 1例慢性乙型肝炎及慢性重型肝炎患者的血清sICAM - 1。结果 各组患者的sICAM - 1水平均高于正常人 (P <0 0 1)。而各组患者之间的sICAM水平 ,以慢性重型肝炎患者最高 ,中度慢性肝炎次之 (P <0 0 1) ,轻度慢性肝炎较低 (P <0 0 1)。sICAM水平与血清丙氨酸转氨酶及总胆红素水平呈显著正相关 (P <0 0 1) ,与血清白蛋白水平呈显著负相关 (P <0 0 1) ,与体内乙肝病毒的存在及复制无关。结论 sICAM - 1是一项敏感的、非损伤性的反映肝炎活动性及肝脏损害程度的指标
Objective To investigate the relationship between soluble intercellular adhesion molecule - 1 (sICAM - 1) and viral hepatitis. Methods Serum sICAM - 1 was detected by ELISA in 61 patients with chronic hepatitis B and chronic severe hepatitis. Results The levels of sICAM - 1 in all groups were significantly higher than those in normal controls (P <0.01). The levels of sICAM in each group were highest in patients with chronic severe hepatitis, followed by moderate chronic hepatitis (P <0.01), and mild chronic hepatitis was lower (P <0.01). There was a significant positive correlation between sICAM level and serum levels of alanine aminotransferase and total bilirubin (P <0.01), a significant negative correlation with serum albumin (P <0.01), and the presence of hepatitis B virus Copy has nothing to do. Conclusion sICAM - 1 is a sensitive and non - invasive indicator of hepatitis activity and liver damage