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嗜酸性筋膜炎是一种结缔组织病,其临床特征是多累及前臂和小腿,呈对称性肿胀、发硬和皮肤增厚,有时也波及躯干,但指、趾多不受累,常因肢体皮肤变硬而导致活动受限.为阐明本病中胶原活化的作用,作者研究了从2例嗜酸性筋膜炎患者受犯皮肤培养的真皮纤维母细胞中前胶原基因的表达.该2例患者病变区组织相显示真皮、皮下、筋膜及其下肌肉中炎性细胞浸润和不同程度的胶原堆积.从同一病人的病变区和非变病变区建立的纤维母细胞培养显示胶原产生前者比后者高2～3.7倍,Ⅰ型前胶原mRNA的稳态水平前者比后者高2.4～6.2倍,显示了Ⅰ型前胶原基因表达前转译的活化.
Eosinophilic fasciitis is a connective tissue disease, its clinical features are more involved in the forearm and lower leg, symmetrical swelling, stiff hair and thickening of the skin, and sometimes spread to the trunk, but refers to the toes and more are not involved, often due to limbs In order to elucidate the role of collagen activation in this disease, we examined the expression of procollagen genes in dermal fibroblasts from 2 cases of eosinophilic fasciitis infested skin Tissue lesions in the diseased zone showed infiltration of inflammatory cells in the dermis, subcutaneous, fascia and underlying muscles, and collagen deposition to varying degrees. Fibroblast cultures established from the same patient’s lesion and non-lesioned lesions showed that collagen produced the former ratio The latter was 2 to 3.7 times higher, and the former type I procollagen mRNA was 2.4 to 6.2 times higher than the latter, indicating the activation of type I procollagen gene expression pretranslation.