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在体外受精-胚胎移植中用生长激素(GH)可促进子宫内膜发育,改善子宫内膜的功能,提高子宫内膜的容受状态,从而提高妊娠率。同时,GH刺激子宫内膜癌细胞基因的表达,使子宫内膜癌细胞总数增加,肿瘤体积增加,并且促进了癌细胞的迁移或浸润,提高了子宫内膜癌细胞的致癌性。GH拮抗剂可能会在子宫内膜癌晚期提供一个有用的治疗方案,以改善患者的预后,这将是一个新的研究课题。
In vitro fertilization - embryo transfer with growth hormone (GH) can promote the development of the endometrium, improve endometrial function, improve endometrial tolerance status, thereby increasing the pregnancy rate. At the same time, GH stimulates the expression of endometrial cancer cells, increasing the total number of endometrial cancer cells, increasing the tumor volume, and promoting the migration or infiltration of cancer cells and enhancing the carcinogenicity of endometrial cancer cells. GH antagonists may provide a useful treatment in the advanced stage of endometrial cancer to improve the prognosis of patients, which will be a new research topic.