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碘化油(Lipiodol,以下简称碘油)国产品含有机碘37～41％,广泛用于支气管、子宫与输卵管、淋巴管、窦道以及瘘管等造影。近年来,有人试用碘油化的抗癌药物经肝动脉插管注入以诊治肝细胞癌已取得了重要进展。本文就其诊治肝癌的原理,方法和临床应用价值作一介绍。历史回顾碘油为油性造影剂,一般认为禁忌注入血管中,否则易产生油检综合征。1966年 Idezu-ki 向实验犬的门静脉内注入碘油,可见门静脉系统较长时间显影,用以诊断肝内占位性病变,无副作用。用碘油微粒作门静脉动力学闪烁扫描研究,可见碘油弥漫分布于全肝,约一周后消失。1979年中熊等对6例肝癌患者经肝动脉向肝内注入碘油,并结扎
Lipiodol (Lipiodol, hereinafter referred to as lipiodol) products contain organic iodine 37 ~ 41%, widely used in bronchoscopy, uterus and fallopian tubes, lymphatic vessels, sinus tract and fistula and other angiography. In recent years, there have been significant advances in the trial of iodized anticancer drugs injected through the hepatic artery to treat hepatoma. This article introduces the principle, method and clinical application value of liver cancer diagnosis and treatment. Historical review Lipiodol is an oil-based contrast agent and is generally considered contraindicated in blood vessels. Otherwise, it is prone to oil syndrome. In 1966, Idezu-ki injected iodized oil into the portal vein of the experimental dog. It can be seen that the portal vein system was developed for a longer period of time to diagnose intrahepatic space-occupying lesions without side effects. Using lipiodol particles for portal vein dynamic scintigraphy studies, it was found that lipiodol diffused throughout the liver and disappeared after about one week. In 1979, Xiong and his colleagues injected lipiodol into the liver through the hepatic artery in 6 cases of liver cancer.