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非处方（OTC）止痛药一般是一类安全的药物，广泛用于治疗发热和疼痛。值得注意的是，OTC止痛药对肾脏具有潜在性毒性，长期大剂量滥用或与止痛药合用可引起许多肾综合征。非甾体抗炎药（NSAIDs）最易产生体液和电解质紊乱、急性肾衰、急性间质性肾炎。OTC止痛药肾毒性的危险因素包括容量低下、老年、充血性心衰、咖啡因等，应了解这些危险因素，根据药物的安全性使用适合的OTC止痛药。
Over-the-counter (OTC) painkillers are generally a class of safe drugs that are widely used to treat fever and pain. It is noteworthy that OTC analgesics are potentially toxic to the kidneys and that long-term high-dose abuse or combination with analgesics can cause many renal syndromes. Non-steroidal anti-inflammatory drugs (NSAIDs) most likely to produce fluid and electrolyte disorders, acute renal failure, acute interstitial nephritis. OTC analgesics Nephrotoxicity risk factors include low volume, senile, congestive heart failure, caffeine, etc. should be aware of these risk factors, according to the safety of the drug using a suitable OTC painkiller.