中科院动物所研究员孙青原领导的受精生物学研究组发现,环境能诱导精子发生表观遗传学改变,并且这种改变可遗传到下一代。相关成果日前已发表于美国《国家科学院院刊》。在全球范围内,前期糖尿病和Ⅱ型糖尿病越来越普遍。此前人们已经发现,父亲的空腹血糖升高和糖耐受的降低,会影响后代的糖代谢,但研究者们还不清楚这些影响背后的确切分子机制。孙青原团队构建了环境诱导的前期糖尿病的雄性小鼠模型,发现父本的前期糖尿病症状影响了后代的表观遗传学修饰,从而增加了后代患 The team of fertilization biology led by Sun Qingyuan, a researcher at the Institute of Zoology at the Chinese Academy of Sciences, found that the environment can induce epigenetic changes in spermatogenesis that can be passed on to the next generation. Related results have been published in the United States, “Proceedings of the National Academy of Sciences.” Globally, pre-diabetes and type II diabetes are becoming more prevalent. It has been previously found that elevated fasting glucose and impaired glucose tolerance affect the glucose metabolism of the offspring, but the exact molecular mechanism underlying these effects is unclear to researchers. Sun Qingyuan team constructed a model of environmental-induced pre-diabetes in male mice and found that the paternal pre-diabetes symptoms affect the offspring of epigenetic modifications, thus increasing offspring