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目的:分析我院药品不良反应(ADR)发生的特点和报告质量,促进临床安全用药。方法:采用回顾性分析方法,对我院2011~2013年收集的497例ADR报告按患者的性别、年龄、药物过敏史、给药途径、ADR报告分级、药品种类、临床表现、关联性评价等情况进行统计分析。结果:497例ADR报告中,由抗感染药物引起的ADR占50.10%(249/497),中药制剂引起的ADR占15.09%(75/497);ADR的表现以皮肤及其附件的损害最为常见,占50.84%(302/594);497例ADR中,新的ADR 27例,严重的ADR 15例,新的、严重的ADR报告数较少;严重ADR的表现以过敏性休克居多。结论:应加大ADR的监测力度,提高ADR报告质量,加强药物的合理使用,减少或避免ADR的发生。
Objective: To analyze the characteristics and reporting quality of adverse drug reaction (ADR) in our hospital and to promote clinical safety medication. Methods: A retrospective analysis of 497 cases of ADR collected in our hospital from 2011 to 2013 according to the patient’s gender, age, drug allergy history, route of administration, classification of ADR reports, type of drug, clinical manifestations, relevance evaluation Statistical analysis of the situation. Results: ADR caused by anti-infective drugs accounted for 50.10% (249/497) in 497 ADR cases and 15.09% (75/497 ADR) caused by traditional Chinese medicine preparations. The most common manifestation of ADR was the damage of skin and its appendages , Accounting for 50.84% (302/594). Of the 497 ADRs, 27 were new ADRs and 15 were severe ADRs. There were fewer new and severe ADR reports. Serious ADRs were mostly attributed to anaphylactic shock. Conclusion: We should intensify the monitoring of ADR, improve the quality of ADR reports, enhance the rational use of drugs and reduce or avoid the occurrence of ADR.