急性感染性多发性神经根神经炎(Acute infections polyradiculoneuritis)或略称为急性感染性多神经炎(Acute infections polyneuritis)。1859年Landry氏首报时曾强调了本病的上升性痪瘫,因而曾有兰德里氏上行性瘫痪(Landry’s ascending paralysis)之名。1916年,Guillain氏与Barre氏等再报时已发现本病脑脊液中有蛋白——细胞分离的特征性现象。1927年以后,多数作者倡用格林——巴利二氏综合征(Guillain-Barre syndrome缩写为GBS)称呼本病,沿用至今。本病为感染后发生的急性弥漫性的多神经根神经病(Polyradiculoneuropathy),脊神经根的运动纤维优选性受犯,亦可侵及颅神经,临床上以上行性瘫痪及脑脊液中蛋白细胞分离为特征,重症者可因呼吸肌瘫痪而致命。本病在美国之发病率是1.6/10万人/年。近30年来,国内报告已超过3000例,似有逐年增高之趋势。今就病因、发病机理、病理、临床表现、临床分型、诊断与鉴别诊断和治疗等分别讨论如下: Acute infectious polyradiculoneuritis or abbreviated as acute infectious polyneuritis. Landry’s ascending paralysis (Landry’s ascending paralysis) was once emphasized in 1859 by Landry’s first report. In 1916, Guillain’s and Barre’s re-reported that this disease has cerebrospinal fluid protein-cell separation of the characteristic phenomenon. Since 1927, most authors have advocated the use of Guillain-Barre syndrome (GBS) as the term for this disease, which has been in use ever since. The disease is an acute and diffuse polyradiculoneuropathy that occurs after infection. The motility fibers of the spinal nerve roots are favored for preference, and may also invade the cranial nerves and are clinically characterized by paralysis and protein-cell separation in cerebrospinal fluid Severe cases may be fatal due to respiratory muscle paralysis. The incidence of this disease in the United States is 1.6 / 10 million people / year. In the past 30 years, more than 3,000 domestic reports have been reported, which seem to be increasing year by year. This etiology, pathogenesis, pathology, clinical manifestations, clinical classification, diagnosis and differential diagnosis and treatment were discussed as follows: