Long-term fundus fluorescence angiography and real-time diagnosis of retinal diseases in non-human p

来源 :纳米研究(英文版) | 被引量 : 0次 | 上传用户:zxzcmj
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Fluorescein angiography (FA) is a standard imaging modality for evaluating vascular abnormalities in retina-related diseases,which is recognized as the major cause of vision loss.Long-term and real-time fundus angiography is of great importance in preclinical research,nevertheless remaining big challenges up to present.In this study,we demonstrate that long-term fluorescence imaging of retinal vessels is enabled through a kind of fluorescent nanoagents,which is made of small-sized (hydrodynamic diameter:~ 3 nm)silicon nanoparticles (SiNPs) featuring strong fluorescence,robust photostability,lengthened blood residency and negligible toxicity.In particular,the presented SiNPs-based nanoagents are capable of imaging retinal capillaries in ~ 10 min,which is around 10-fold longer than that (~ 1 min) of fluorescein sodium (FS,known as the most widely used contrast agents for FA in clinic).Taking cynomolgus macaques as non-human primate-animal model,we further demonstrate the feasibility of real-time diagnosis of retinal diseases (e.g.,age-related macular degeneration (AMD)) through dynamic monitoring of vascular dysfunction.
其他文献
In the recent times sodium ion batteries (SIBs) have come to the forefront as an economic and resourceful alternative to lithium-ion batteries (LIBs) for powering portable electronic devices and large-scale grid storage.As the specific capacity,energy den
We propose a plasmonic atomic force microscopy (AFM) probe,which takes a part of the laser beam for monitoring cantilever deflection as the excitation light source.Photonic crystal cavities are integrated near the cantilever\'s free end where the laser
The next generation of electronics technology is purely going to be based on wearable sensing systems.Wearable electronic sensors that can operate in a continuous and sustainable manner without the need of an external power sources,are essential for porta
Graphene quantum dots (GQDs),have unique quantum confinement effects,tunable bandgap and luminescence property,with a wide range of potential applications such as optoelectronic and biomedical areas.However,GQDs usually have a strong tendency toward aggre
The energy crisis has always been a widely concerned problem.It is an urgent need for green and renewable energy technologies to achieve sustainable development,and the photo-assisted charging energy storage devices provide a new way to realize the sustai
Radiotherapy (RT) based on X-ray irradiation is a widely applied cancer treatment strategy in the clinic.However,treating cancer based on RT alone usually results in insufficient radiation energy deposition,which inevitably has serious side effects on hea
Molybdenum disulfide (MoS2) has received enormous attentions in the electrochemical energy storage due to its unique two-dimensional layered structure and relatively high reversible capacity.However,the application of MoS2 in potassium-ion batteries (PIBs
As a famous hole transporting material,nickle oxide (NiOx) has drawn enormous attention due to its low cost and superior stability.However,the relatively low conductivity and high-density surface trap states of NiOx severely limit device performance in so
Metal halide perovskite nanocrystals have attracted great attention of researchers due to their unique optoelectronic properties such as high photoluminescence quantum yield (PLQY),narrow full width at half-maximum (FWHM),long exciton diffusion length and
Graphene is a material with unique properties that can be exploited in electronics,catalysis,energy,and bio-related fields.Although,for maximal utilization of this material,high-quality graphene is required at both the growth process and after transfer of