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目的探讨高血压性脑出血（HICH）急性期抗凝及纤溶状态的动态变化规律。方法抗凝血酶Ⅲ活性（ATⅢ：A）测定采用凝血酶凝胶空斑法，抗凝血酶Ⅲ抗原含量（ATⅢ：Ag）测定采用免疫火箭电泳法；纤溶酶原活性（PLG：A）测定采用醋蛋白分解法；D－二聚体（D－D）水平测定采用酶联免疫吸附双抗体夹心法（ELISA）。结果HICH发病后24小时内及第3天，血中ATⅢ：Ag较正常对照组显著降低，而D—D则显著升高，第7天均与对照组无显著性差异。PLG：A各组均与对照组无显著性差异。结论HICH急性或ATⅢ呈短暂性降低，D－D暂时性升高，是抗凝、纤溶系统对HICH时脑组织损伤引起血中凝血活性升高的一种代偿反应。
Objective To investigate the dynamic changes of anticoagulant and fibrinolytic state in patients with hypertensive intracerebral hemorrhage (HICH) in acute phase. Methods The antithrombin Ⅲ activity (ATⅢ: A) was determined by thromboplastin, antithrombin Ⅲ antigen (AT Ⅲ: Ag) ) Determination of the use of vinegar protein decomposition; D-dimer (D-D) levels were measured by enzyme-linked immunosorbent double antibody sandwich method (ELISA). Results Within 24 hours after the onset of HICH and on the third day, ATⅢ: Ag in blood was significantly lower than that of the normal control group, while D-D was significantly increased. There was no significant difference between the 7th day and the control group. PLG: A each group and the control group no significant difference. Conclusions HICH acute or AT Ⅲ is transiently decreased and D-D is transiently elevated. It is a compensatory response of anticoagulant and fibrinolytic system to the increase of blood coagulation activity caused by brain injury in HICH.