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目的:观察国产奥美拉唑对小儿上消化道出血的疗效和安全性。方法:将78例经胃镜确诊的上消化道出血患儿随机分为治疗组40例,对照组38例,治疗组给予国产奥美拉唑0.9 mg.kg-1.次-1,静脉注射,1次/12 h;对照组给予法莫替丁0.9 mg.kg-1.次-1,静脉注射,1次/12 h。疗程均为5 d。每天观察呕血、黑便、血压、脉搏、肠鸣音等改变及有无不良反应。结果:治疗组显效率、总有效率、平均止血天数分别为57.5%、95.0%、(1.36±0.59)d;对照组分别为39.5%、76.3%、(2.98±0.54)d。治疗组显效率、总有效率均明显高于对照组(P<0.05),止血时间明显短于对照组(P<0.05)。治疗组无明显不良反应。结论:国产奥美拉唑是治疗小儿上消化道出血安全有效的药物。
Objective: To observe the efficacy and safety of domestic omeprazole on children with upper gastrointestinal bleeding. Methods: A total of 78 children with upper gastrointestinal bleeding diagnosed by endoscopy were randomly divided into treatment group (40 cases) and control group (38 cases). The treatment group was given omeprazole 0.9 mg.kg-1, 1/12 h; control group was given famotidine 0.9 mg.kg-1 times -1, intravenous injection, 1/12 h. Treatment are 5 d. Daily observation of hematemesis, melena, blood pressure, pulse, bowel sounds and other changes and whether the adverse reactions. Results: The effective rate, the total effective rate and the average number of days of hemostasis were 57.5%, 95.0% and 1.36 ± 0.59 d respectively in the treatment group and 39.5%, 76.3% and 2.98 ± 0.54 d in the control group respectively. The effective rate and total effective rate of the treatment group were significantly higher than that of the control group (P <0.05), and the bleeding time was significantly shorter than that of the control group (P <0.05). Treatment group no obvious adverse reactions. Conclusion: Domestic omeprazole is safe and effective in the treatment of upper gastrointestinal bleeding in children.