论文部分内容阅读
目的探讨脑心通胶囊治疗有症状冠状动脉肌桥合并颈动脉硬化的疗效,并随访,对其预后进行分析。方法选择2014年1月~2015年1月我院收治确诊的有症状冠状动脉肌桥合并颈动脉硬化患者80例,将其随机分为观察组与对照组,各40例。观察组在西医规范治疗基础上口服脑心通胶囊。观察两组患者治疗前后血脂变化、颈动脉病变情况、心绞痛等症状发作次数及最后一次随访时冠状动脉CTA显示肌桥压缩程度等,并进行分析。结果两组患者经治疗后,TC、TG、LDL-C均有明显降低,HDL-C升高;颈动脉IMT厚度变薄,斑块缩小,心肌桥压缩程度改善,与治疗前比较,差异有统计学意义(P<0.05)。观察组随访期间心绞痛发作次数明显少于对照组,LDL-C及IMT减少明显大于对照组,差异均有统计学意义(P<0.01)。结论脑心通胶囊联合西医规范治疗能有效调控有症状冠状动脉肌桥合并颈动脉硬化患者的血脂,具有逆转动脉粥样硬化,缩小斑块的作用,对预防心脑血管事件及改善患者生活质量有积极意义,长期随访未发现不良反应,值得临床推广。
Objective To investigate the effect of Naoxintong capsule on the treatment of symptomatic coronary artery muscular bridge combined with carotid atherosclerosis and follow-up, and analyze its prognosis. Methods From January 2014 to January 2015, 80 patients with symptomatic coronary artery muscular bridge and carotid atherosclerosis admitted to our hospital from January 2014 to January 2015 were randomly divided into observation group and control group, with 40 cases in each group. Observation group in the Western standard treatment based on oral Naoxintong capsule. The changes of blood lipid, carotid artery disease, the number of angina pectoris and the degree of myocardial bridge compression at the last follow-up were observed and analyzed before and after treatment. Results After treatment, the TC, TG and LDL-C in both groups were significantly decreased and HDL-C was increased. The carotid IMT thickness was thinner, the plaque was reduced and the myocardial bridge compression was improved. Compared with before treatment, the difference was Statistical significance (P <0.05). During the follow-up of observation group, the number of angina pectoris was significantly less than that of control group, and the decrease of LDL-C and IMT was significantly greater than that of control group. The difference was statistically significant (P <0.01). Conclusion Naoxintong Capsule combined with western medicine can effectively regulate the blood lipid of patients with symptomatic coronary artery muscular bridge and carotid atherosclerosis. It has the effect of reversing atherosclerosis and reducing plaque, preventing cardiovascular and cerebrovascular events and improving the quality of life There is positive significance, long-term follow-up found no adverse reactions, it is worth clinical promotion.