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目的研究原发性甲状旁腺机能亢进(PHPT)骨骼病变的CT、MRI特征性表现及诊断价值。方法健康成年中国白兔80只,随机分成两组,对照组40只以正常饮食(Ca∶P,1∶0.7)喂养,实验组40只以高磷饮食(Ca∶P,1∶7)喂养诱发原发性甲状旁腺机能亢进动物模型。在第3、4、5、6个月,分别对实验组和对照组动物行高场MR及螺旋CT骨扫描分析影像学特征。同时对所有动物甲状旁腺及骨标本行病理学检查,评价影像诊断的准确性。结果送检的甲状旁腺明显增生。骨骼均存在骨质疏松和骨皮质吸收的表现,MRT1WI表现不同程度局限性低信号改变,T2WI早期表现为不同程度的局限性低信号或中等信号改变,如骨髓水肿表现为高信号改变,随病情进展纤维组织取代骨组织则为低信号改变。相应螺旋CT扫描依次为阴性,可疑,骨质疏松,骨膜下皮质吸收表现。而对照组动物甲状旁腺及骨骼均未见异常。结论高场MR结合螺旋CT扫描既可发现早期病变又可进行分期,是研究早期PHPT骨骼病变的可靠手段。
Objective To study CT and MRI features and diagnostic value of primary hyperparathyroidism (PHPT) skeletal lesions. Methods Eighty healthy adult Chinese white rabbits were randomly divided into two groups, 40 in control group were fed with normal diet (Ca: P, 1: 0.7), 40 in experimental group were fed with high phosphorus diet (Ca: P, Induced primary hyperparathyroidism in animal models. At the 3rd, 4th, 5th, 6th month, the imaging characteristics of the experimental group and the control group were analyzed by high field MR and spiral CT bone scan respectively. At the same time, all animal parathyroid and bone specimens were examined by pathology to evaluate the accuracy of imaging diagnosis. The results of parathyroid gland hyperplasia. Bone are osteoporosis and cortical bone absorption, MRT1WI performance of varying degrees of low signal changes in the limited, T2WI early showed varying degrees of limitations of low or moderate signal changes, such as bone marrow edema showed high signal changes, with the disease Progressive fibrous tissue replaces bone tissue with a low signal change. The corresponding spiral CT scan followed by negative, suspicious, osteoporosis, subperiosteal cortical absorption performance. In the control group, no abnormality was found in parathyroid gland and bone. Conclusion High-field MR combined with spiral CT scan can detect both early lesions and staging, which is a reliable method to study the early stage of PHPT skeletal diseases.