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多毛症为雄激素过多或毛发对正常水平的雄激素敏感性增加的结果。而多毛症的治疗还不尽人意。安体舒通广泛应用于多毛症的治疗,其为一种保钾利尿剂,主要是在外周作用及干扰双氢睾酮与其细胞内受体的结合而减少毛发生长。Diane 35(醋酸氯羟甲烯孕酮2 mg加乙炔雌二醇35μg)加安体舒通与单独Diane 35应用比较,在降低Ferriman-Gallwey评分上是一个有效的选择。 门诊50例多毛症妇女(修改的Ferri-man-Gallwey评分>8),排除了肾上腺皮质功能亢进、雄激素分泌性肿瘤、泌乳素瘤等疾患。患者无阴蒂肥大或其它男性化的表现。研究前至少6个月未服影响垂体性腺功能的药物。
Hirsutism is the result of an androgen hyperacidity or increased sensitivity of the hair to normal levels of androgens. The treatment of hirsutism is not satisfactory. Spironolactone is widely used in the treatment of hirsutism, which is a potassium-sparing diuretic, mainly in the peripheral and interfere with the combination of dihydrotestosterone and its intracellular receptors to reduce hair growth. Diane 35 (2 mg progesterone acetate plus 35 μg ethinyl estradiol) plus diazepam compared with Diane 35 alone was a good choice for lowering the Ferriman-Gallwey score. Outpatients 50 women with hirsutism (modified Ferri-man-Gallwey score> 8), excluding adrenocortical hyperfunction, androgen-secreting tumors, prolactinomas and other diseases. Patients have no clitoral hypertrophy or other masculine manifestations. At least 6 months before the study did not affect the pituitary gland function of the drug.