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血清雌激素和黄体酮浓度的生理变化能否影响胆汁中类脂成分,目前尚有争论,因此作者测定年青妇女月经周期中胆汁胆固醇饱和指数(CSI)的变化,并重新估价其精确性。方法:胆汁取样:健康志愿者男5名,20～31岁;女10名,20～35岁。妇女不服激素类避孕药至少2月。标准饮食12小时后收集胆汁,每3～4天一次,一月中共8次。女性第一次胆汁在月经周期第2或第3天收集。志愿者每次吞入十二指肠管,顶端放于十二指肠第三部。按每公斤体重1 U胆囊收缩素静脉缓注后,从十二指肠抽取胆汁5管,每管3ml。最深的胆汁立即送实验室作胆固醇、总胆酸和磷脂分析,其余的胆汁在拔
It is currently debated whether physiological changes in serum estrogen and progesterone concentrations affect bile lipid composition. Therefore, the authors measure changes in biliary cholesterol saturation index (CSI) in young women’s menstrual cycle and reevaluate their accuracy. Methods: Bile sampling: five healthy volunteers, 20 to 31 years old; female 10, 20 to 35 years old. Women refuse to take hormonal contraceptives for at least February. Bile was collected 12 hours after the standard diet, once every 3 to 4 days and 8 times in January. The first female bile collected on the 2nd or 3rd day of the menstrual cycle. Volunteers swallowed the duodenum each time, placing the tip on the third part of the duodenum. According to 1 kg per kg body weight of cholecystokinin slow intravenous injection, bile 5 tubes from the duodenum, each tube 3ml. The deepest bile immediately sent to the laboratory for cholesterol, total bile acid and phospholipid analysis, the remaining bile in the pull