论文部分内容阅读
目的：研究脂质体对酮洛芬体外透皮特性的影响。方法：采用薄膜分散－超声法制备酮洛芬脂质体，以高效液相色谱法测定皮肤接受液中药物浓度，计算酮洛芬透过离体小鼠背部皮肤单位面积的累积量和渗透系数。结果：药物浓度等实验条件相同时，粒径大的脂质体比粒径小者渗透系数略小；实验过程中供给池不封闭，以模拟脂质体给药过程中失水，药物渗透系数较封闭者升高。结论：脂质体失水、脂质体粒径是影响酮洛芬体外透皮的主要因素。
OBJECTIVE: To study the effects of liposomes on the in vitro transdermal characteristics of ketoprofen. METHODS: The ketoprofen liposomes were prepared by the membrane dispersion-ultrasound method. The concentration of drug in the skin receiving fluid was determined by HPLC. The cumulative amount of ketoprofen per unit area of the back skin and the osmotic coefficient . Results: When the drug concentration and other experimental conditions were the same, the permeability coefficient of the liposome with larger particle size was smaller than that with the smaller particle size. The donor cell was not closed during the experiment to simulate the water loss in the liposome delivery process. The drug permeability coefficient Closer than those who rise. Conclusion: The liposomes lose water and liposome size is the main factor that affects the in vitro transdermal delivery of ketoprofen.