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目的:观察缺血性脑梗死急性期尿激酶介入动脉溶栓治疗的临床疗效。方法:应用尿激酶早期动脉内溶栓治疗急性脑梗死26例。溶栓前及溶栓后2 h、30 d进行神经功能缺损评分,同时观察并发症及疗效。结果:颈内动脉闭塞9例,大脑中动脉主干(M1)段闭塞6例,大脑前动脉闭塞4例,椎基底动脉系统闭塞3例。溶栓治疗后10例获得完全再通,9例部分再通,3例未开通。临床症状完全恢复及明显好转16例,占总病例61.5%。术后NIHSS评分较术前明显提高。并发颅内出血1例。再通后发生再闭塞1例。结论:尿激酶动脉溶栓治疗急性脑梗死安全、有效、可行,但其远期疗效还需进一步观察。
Objective: To observe the clinical effect of urokinase interventional arterial thrombolysis in the acute stage of ischemic stroke. Methods: 26 cases of acute cerebral infarction were treated with early thrombolysis of urokinase. Thrombolysis and thrombolysis 2 h, 30 d for neurological deficit score, and observe the complications and efficacy. Results: There were 9 cases of internal carotid artery occlusion, 6 cases occluded in the middle cerebral artery (M1) segment, 4 occluded anterior cerebral arteries and 3 occluded vertebrobasilar system. After thrombolytic therapy, 10 cases were completely recanalized, 9 cases recanalized, and 3 cases were not opened. Complete recovery of clinical symptoms and significant improvement in 16 cases, accounting for 61.5% of the total cases. Postoperative NIHSS score was significantly improved compared with preoperative. 1 case of intracranial hemorrhage. Recanalization after recanalization occurred in 1 case. Conclusion: Arterial thrombolysis in the treatment of acute cerebral infarction is safe, effective and feasible, but its long-term efficacy needs further observation.