论文部分内容阅读
目的:探析甲状腺激素(TH)及垂体激素水平变化在中型颅脑损伤(MHI)、重型颅脑损伤(SHI)患者病情判断及预后情况观察中的临床价值。方法:分析2010年1月~2015年12月在我院接受诊治的50例HI患者的临床资料。根据颅脑损伤(HI)病情严重程度将入选者分成MHI组(22例)和SHI组(28例)。根据预后情况将入选者分成存活组(S组,40例)和死亡组(D组,10例)。另外选取同期在我院接受健康体检的45例健康者作为本次研究的对照组。比较MHI组、SHI组、对照组及S组和D组患者的TH(总三碘甲腺原氨酸TT3、总甲状腺素TT4、游离三碘甲腺原氨酸FT3和游离甲状腺素FT4)、促甲状腺激素(TSH)、血清泌乳素(PRL)及促卵泡生成素(FSH)等指标的表达水平。结果:MHI组、SHI组与对照组的一般资料无显著差异。MHI组患者的TT3、FT3明显较SHI组患者高,PRL及FSH明显较SHI组低,而TT4、FT4及TSH水平无显著差异。MHI组、SHI组患者的TT3、FT3明显较对照组低,PRL及FSH明显较对照组高,而TT4、FT4及TSH水平无显著差异。S组患者的TT3、FT3、PRL及FSH水平明显优于D组,而TT4、FT4及TSH水平无显著差异。结论:HI患者的预后情况随着其病情的加重而变差,且血清TT3、FT3、PRL及FSH可作为HI患者病情判断及其预后观察的重要指标。
Objective: To investigate the clinical value of the changes of thyroid hormone (TH) and pituitary hormone levels in judging the prognosis and prognosis of patients with moderate head injury (MHI) and severe head injury (SHI). Methods: From January 2010 to December 2015 in our hospital for treatment of 50 cases of HI clinical data. According to the severity of craniocerebral injury (HI), the patients were divided into MHI group (22 cases) and SHI group (28 cases). The patients were divided into survival group (S group, 40 cases) and death group (D group, 10 cases) according to the prognosis. In addition, we selected 45 healthy subjects in our hospital during the same period as the control group in this study. TH (total triiodothyronine TT3, total thyroxine TT4, free triiodothyronine FT3 and free thyroxine FT4) in MHI, SHI, control and S and D groups were compared, Thyroid stimulating hormone (TSH), serum prolactin (PRL) and follicle stimulating hormone (FSH) and other indicators of the expression level. Results: The general data of MHI group, SHI group and control group showed no significant difference. The TT3 and FT3 in MHI group were significantly higher than those in SHI group, the PRL and FSH were significantly lower than those in SHI group, while the levels of TT4, FT4 and TSH were not significantly different. The levels of TT3 and FT3 in MHI group and SHI group were significantly lower than those in control group. PRL and FSH were significantly higher than those in control group, but there was no significant difference in TT4, FT4 and TSH levels. The levels of TT3, FT3, PRL and FSH in group S were significantly better than those in group D, while there were no significant differences in the levels of TT4, FT4 and TSH. Conclusion: The prognosis of patients with HI is worsened with the worsening of their disease. And serum TT3, FT3, PRL and FSH can be used as important indicators to judge the prognosis of HI patients.