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二萜生物碱为乌头属植物重要的物质基础。现代药理研究表明乌头二萜生物碱具有抗炎、镇痛、抗心律失常的作用,其中在镇痛方面的活性尤为突出。为促进乌头二萜生物碱的新药研究和开发利用,本文对乌头二萜生物碱的化学成分及镇痛活性的研究进展进行综述。
Diterpene alkaloids are the important material basis of the genus Aconitum. Modern pharmacological studies have shown that aconitic diterpenoid alkaloids with anti-inflammatory, analgesic, anti-arrhythmic role, of which the activity is particularly prominent in the analgesic. In order to promote the new drug research and development and utilization of diterpenoid alkaloids in aconite, the research progress of chemical constituents and analgesic activity of diterpene alkaloids in aconite were reviewed in this paper.