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目的总结和分析乳腺导管原位癌伴微小浸润(T_1 mic)的临床和组织病理特征,探讨合理的治疗方法。方法总结自1996年1月至2006年6月底共31名患者32例乳腺导管原位癌伴微小浸润的临床特征,组织病理特征,治疗方法及随访资料。结果经病理诊断的32例乳腺导管原位癌伴微小浸润患者中,最大浸润灶均≤1 mm,其中有27例(84%)临床上可触及肿块,有30例(93.8%)钼靶上有异常表现,病理可见粉刺样结构的病例为19例(59.4%),可见坏死的为20例(62.5%)。25例行腋窝淋巴结清扫术的患者没有一例有腋窝淋巴结转移。经过中位时间为28个月的随访无一例发生复发和转移。结论乳腺导管原位癌伴微小浸润是一个少见的乳腺癌亚型,其预后很好。治疗上应该根据其原位癌成分的病理特点及临床特征进行治疗。
Objective To summarize and analyze the clinical and histopathological features of ductal carcinoma in situ with minimal invasion (T_1 mic) and to explore a reasonable treatment. Methods From January 1996 to the end of June 2006, 32 cases of breast ductal carcinoma in situ with minimal invasion of breast cancer were retrospectively analyzed. The clinical features, histopathological features, treatment and follow-up data were summarized. Results The pathological diagnosis of 32 cases of ductal carcinoma in situ with minimal invasion of patients, the maximum infiltration of lesions were ≤ 1 mm, of which 27 cases (84%) clinically palpable mass, 30 cases (93.8%) on the molybdenum target There are abnormalities, the pathology shows acne-like structure of the cases were 19 cases (59.4%), necrosis was seen in 20 cases (62.5%). None of the 25 patients with axillary lymph node dissection had axillary lymph node metastases. After a median of 28 months follow-up no recurrence and metastasis. Conclusion Breast duct carcinoma in situ with minimal infiltration is a rare subtype of breast cancer with a good prognosis. The treatment should be based on the pathological features of its carcinoma in situ and clinical features of the treatment.