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目的探讨临床上使用奥美拉唑治疗消化性溃疡出血的疗效。方法将我院2011年2月到2012年3月收治128例经过胃镜检查证实为消化性溃疡出血的患者随机分为观察组和对照组,观察组(64例),对照组(64例)。两组患者均经过禁食、输血、补液、营养支持等综合治疗,在此基础上治疗组患者12h/次静脉注射40mg奥美拉唑进一步治疗,对照组12h/次静脉滴注20mg法莫替丁治疗,在治疗期间不使用其他任何抑酸剂以及止血药。治疗前两组患者均放置胃管,2h/次抽吸,当抽吸液变清作为止血的指标,同时观察患者神志、血压、出血等情况,以及产生的药物不良反应,密切的监控患者肝肾功能以及血红蛋白的情况。结果观察组和对照组治疗的有效率分别为93.75%、84.38%,两组比较差异显著(P<0.05)。观察组患者输血量为(200±12)ml,止血时间(21.6±2.3)h;对照组患者输血量(400±28)ml,止血时间(34.2±3.8)h;两组在输血量和止血时间比较差异显著(P<0.05)。两组患者均未出现病例死亡,两组患者均为出现明显的不良临床症状。结论临床上应用奥美拉唑治疗消化性溃疡出血有比较显著的疗效,无明显的不良反应,值得在临床上广泛推广。
Objective To investigate the clinical efficacy of omeprazole in the treatment of peptic ulcer bleeding. Methods A total of 128 patients with peptic ulcer bleeding confirmed by gastroscopy were randomly divided into observation group and control group. The observation group (64 cases) and the control group (64 cases) were treated in our hospital from February 2011 to March 2012. Both groups were treated with fasting, transfusion, rehydration, nutritional support and other comprehensive treatment, on the basis of the treatment group patients 12h / sub-intravenous injection of 40mg omeprazole for further treatment, the control group 12h / sub-intravenous infusion of 20mg famotidine D treatment, do not use any other antacids and hemostatic agents during treatment. Two groups of patients before treatment were placed gastric tube, 2h / time aspiration, aspiration clear liquid as an indicator of hemostasis, while observing the patient’s consciousness, blood pressure, bleeding and other adverse reactions, the close monitoring of patients with liver Kidney function and hemoglobin situation. Results The effective rates of treatment in observation group and control group were 93.75% and 84.38% respectively, with significant difference between the two groups (P <0.05). The amount of blood transfusion in the observation group was (200 ± 12) ml and the time to stop bleeding was (21.6 ± 2.3) h. The amount of blood transfusion in the control group was (400 ± 28) ml and the time to stop bleeding was 34.2 ± 3.8 h. The time was significantly different (P <0.05). No deaths occurred in both groups, with significant adverse clinical symptoms in both groups. Conclusion Omeprazole in clinical treatment of peptic ulcer bleeding have a more significant effect, no significant adverse reactions, it is widely used in clinical practice.