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目的探讨盐酸氨溴索(沭舒坦)和丹参酮ⅡA磺酸钠时辰雾化吸入佐治小儿毛细支气管炎的疗效。方法将128例小儿毛细支气管炎患儿随机分成两组,其中对照组64例,给予抗病毒、吸氧、平喘、祛痰止咳、维持水电介质平衡等对症综合处理,治疗组64例在对照组基础上加用盐酸氨溴索7.5mg(沭舒坦1ml)加生理盐水2ml,丹参酮ⅡA磺酸钠注射液0.2mg(kg·d)加生理盐水4ml,由空气压缩泵雾化,采用“时辰疗法”(即晨起和睡前进行雾化)分别进行雾化吸入,每次10min,2次/d,疗程3～7d,丹参酮ⅡA磺酸钠注射液0.6mg(kg·d)加至5%葡萄糖注射液50～100ml静脉滴注,1次/d,疗程3～7d。对两组进行疗效比较。结果治疗组64例,治愈48例,治愈率75%,较对照组治愈14例,治愈率21.9%,χ2=34.06,P<0.01有显著性差异。治疗组患儿体温复常、气促减轻、喘憋消失、哮鸣音消失、咳嗽缓解、啰音消失等的时间和住院天数较对照组明显缩短。结论盐酸氨溴索丹参酮ⅡA磺酸钠时辰疗法雾化吸入联合丹参酮ⅡA磺酸钠注射液0.6mg(kg·d)静脉滴注佐治小儿毛细支气管炎、安全、有效,快速缓解症状和体征,提高治愈率。缩短了患儿住院天数。
Objective To investigate the therapeutic effect of ambroxol hydrochloride (Shu Shu Tan) and sodium tanshinone Ⅱ A sulfonate inhalation on treating bronchiolitis in children. Methods 128 cases of children with bronchiolitis were randomly divided into two groups, of which 64 cases in the control group were given anti-virus, oxygen, asthma, expectorant and cough, to maintain the water and electricity balance and other symptomatic integrated treatment of 64 cases in the control group On the basis of the group, ambroxol hydrochloride 7.5mg (Shu Shu Tan 1ml) plus normal saline 2ml, sodium tanshinone Ⅱ A sulfonate injection 0.2mg (kg · d) plus normal saline 4ml atomized by air compression pump, using “ Time therapy ”(ie, early morning and bedtime before atomization) were inhaled, each time 10min, 2 times / d, treatment 3 ~ 7d, tanshinone Ⅱ A sodium sulfonate injection 0.6mg (kg · d) plus To 5% glucose injection 50 ~ 100ml intravenous infusion, 1 / d, course of treatment 3 ~ 7d. The two groups were compared. Results 64 cases of treatment group, 48 cases were cured, the cure rate was 75%, 14 cases cured compared with the control group, the cure rate was 21.9%, χ2 = 34.06, P <0.01 significant difference. The treatment group, children with normal body temperature, reduce shortness of breath, wheezing disappeared wheeze disappeared, cough relief, auscultation disappear, such as the time and hospitalization was significantly shorter than the control group. Conclusion Ambroxol sodium tanshinone Ⅱ A sulfonate time therapy aerosol inhalation combined with tanshinone Ⅱ A sodium sulfonate injection 0.6mg (kg · d) intravenous administration of pediatric bronchiolitis, safe, effective and rapid relief of symptoms and signs, increased Cure rate. Shorten the hospitalization days in children.