痛觉的调制是十分复杂的过程。从脊髓,脑干以至端脑内有一个痛觉的调制系统,或称内源性镇痛系统。自60年代以来,陆续证明,低位脑干的中缝核群,网状巨细胞核,兰斑核,中脑网状结构,中脑导水管周围灰质(PAG),中脑盖,黑质等结构对痛觉都有一定的调制作用。其中的 PAG 接受外周信息,也接受高级 Modulation of pain is a very complex process. From the spinal cord, brain stem and end of the brain there is a pain modulation system, or endogenous analgesic system. Since the 1960s, it has been successively demonstrated that the structure of the nucleus raphe nucleus, reticular giant cell nucleus, plaque nucleus, mesencephalic reticular network, midbrain periaqueductal gray (PAG), midbrain, substantia nigra and other structures in the low brain stem Pain has a certain modulation effect. Among them, the PAG receives peripheral information and also accepts advanced information