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目的探讨不同剂量氨茶碱和肾上腺素在大鼠窒息致心脏停搏模型中的疗效。方法呼气末夹闭气管8min,建立大鼠心脏停搏模型。48只大鼠随机分为氨茶碱和肾上腺素组,比较两组大鼠不同剂量的复苏疗效。结果心电活动恢复率氨茶碱组与肾上腺素组相比,差异无显著性(P>0.05);两组自主循环差异无显著性(P>0.05)。氨茶碱和肾上腺素复苏疗效均与剂量呈正相关。肾上腺素组心脏硬度记分显著高于氨茶碱组,且剂量越大,心脏硬度记分越高。结论在窒息致心脏停搏大鼠模型中,氨茶碱对心电活动和自主循环的恢复与肾上腺素疗效相近;氨茶碱和肾上腺素的复苏疗效与剂量相关;较高剂量肾上腺素容易致“石头心”的发生。
Objective To investigate the effects of different doses of aminophylline and epinephrine in asphyxial rat cardiac arrest model. Methods Endotracheal trachea was closed for 8 minutes to establish rat cardiac arrest model. Forty-eight rats were randomly divided into aminophylline and epinephrine groups, and the effects of different doses of resuscitation were compared between the two groups. Results ECG recovery rate of aminophylline group compared with adrenaline group, no significant difference (P> 0.05); no significant difference between the two groups of spontaneous circulation (P> 0.05). Aminophylline and adrenaline recovery efficacy and dose were positively correlated. The score of cardiac stiffness in epinephrine group was significantly higher than that of aminophylline group, and the greater the dose, the higher the score of cardiac hardness. Conclusions In the asphyxial rat model of cardiac arrest, aminophylline has similar efficacy to epinephrine in the recovery of ECG and autonomic circulation. The efficacy of aminophylline and epinephrine resuscitation is dose-dependent. The higher dose of epinephrine is likely to cause “Heart of Stone” happened.