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亚临床型肝性脑病(SHE)是广泛存在于肝硬变病程中一种神经功能障碍,表现为视觉、知觉等功能缺陷,可伴有脑实质萎缩,易进展为肝性脑病。近年来国外学者发现SHE发病率高达23％～84％,在我国,慢性肝病患者有1000万左右,对SHE进行深入研究,具有重要的临床及社会意义。 1 材料与方法 采用多中心协作研究方式,在湖北省24家医院同时进行,资料分析由武汉市医科所建立多因素分析数据库,在奔腾100计算机上完成。 1.1 对象 各医院按1988年上海全国肝炎会议制定的标准,选择诊断明确的肝炎、血吸虫、酒精性肝硬变病人为研究对象。
Subclinical hepatic encephalopathy (SHE) is a kind of neurological dysfunction which is widely existed in the course of cirrhosis. It manifests as functional deficits such as vision and consciousness. It may accompany the atrophy of brain parenchyma and easy progression to hepatic encephalopathy. In recent years, foreign scholars found that the incidence of SHE as high as 23% to 84%, in our country, there are about 10 million patients with chronic liver disease, in-depth study of SHE, has important clinical and social significance. MATERIALS AND METHODS A multicenter collaborative research approach was performed in 24 hospitals in Hubei Province. The data analysis was conducted by the Wuhan Medical Institute to establish a multivariate analysis database and was completed on the Pentium 100 computer. 1.1 Subjects According to the standards set by the 1988 Shanghai National Hepatitis Conference, all hospitals selected patients with hepatitis, schistosomiasis and alcoholic cirrhosis who had been diagnosed as the study subjects.