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目的:研究慢性乙醇中毒性周围神经病(CAPN)患者的执行功能。方法:以CAPN患者为研究组,同期健康志愿者为对照组,应用威斯康星卡片分类测验(WCST)、连线测验、Stroop数字计数测验、ODDBELL听觉任务、STERBERG视觉任务、双重视听追踪任务研究被试的执行功能。结果:1连线测验:研究组在“基础任务耗时”(t=2.233,P<0.05)、“附加任务耗时”(t=2.818,P<0.01)均显著高于对照组,在“基础任务正确率”(t=3.511,P<0.01)、“附加任务正确率”(t=2.578,P<0.05)均显著低于对照组;2Stroop数字计数测验:研究组在“基线测验耗时”(t=10.755,P<0.01)、“一致性测验耗时”(t=4.578,P<0.01)、“非一致性测验耗时”(t=4.354,P<0.01)均显著高于对照组,在“基线测验正确率”(t=3.706,P<0.01)、“一致性测验正确率”(t=2.287,P<0.05)、“一致性测验正确率”(t=4.661,P<0.01)均显著低于对照组;3WCST测验:研究组在TN(t=3.834,P<0.01)、CFC(t=4.145,P<0.01)、EN(t=5.777,P<0.01)、PE(t=15.112,P<0.01)、CN(t=7.267,P<0.01)均显著高于对照组,在CA(t=6.055,P<0.01)、FMSS(t=6.294,P<0.01)均显著低于对照组;4视听任务:研究组在“ODDBALL反应时间”(t=16.588,P<0.01)、“STERBERG反应时间”(t=16.892,P<0.01)、“双重任务追踪误差”(t=9.02,P<0.01)、“双重任务反应时间”(t=16.845,P<0.01)均显著高于对照组,在“ODDBALL反应正确率”(t=8.499,P<0.01)、“STERGERG反应正确率”(t=23.782,P<0.01)、“双重任务反应正确率”(t=13.749,P<0.01)均显著低于对照组。结论:CAPN患者在中枢神经系统临床表现出现前,已经存在脑部高级智能活动障碍,认知心理学检查有助于其早期诊断。
Objective: To investigate the executive function of patients with chronic alcohol-induced peripheral neuropathy (CAPN). Methods: CAPN patients and healthy volunteers were enrolled in this study. The WCST, connection test, Stroop digital counting test, ODDBELL auditory task, STERBERG visual task, Executive function. Results: 1 connection test: the study group was significantly higher than the control group in time spent on basic tasks (t = 2.233, P <0.05) and time spent on additional tasks (t = 2.818, P <0.01) (T = 3.511, P <0.01) and “correct rate of additional task” (t = 2.578, P <0.05) were significantly lower than those of the control group. The 2Stroop digital counting test: The study group had significant differences in the time spent on baseline test (t = 10.755, P <0.01), time spent on conformance test (t = 4.578, (t = 4.354, P <0.01) were significantly higher than those in the control group (P <0.01). The accuracy of the “consistency test” (T = 3.661, P <0.01) were significantly lower than those in the control group; 3WCST test: (T = 4.145, P0.01), EN (t = 5.777, P 0.01), PE (t = 15.112, P 0.01) = 6.055, P <0.01), FMSS (t = 6.294, P <0.01) were significantly lower than the control group; 4 audiovisual tasks: the study group in the “ODDBALL reaction time” “STERBERG response time” (t = 16.892, P <0.01), “double task tracking error” (t = 9.02, P <0.01) Reaction time "(t = 16.845, P <0.01) were significantly higher than those in the control group, and there were significant differences in the accuracy of ODDBALL reaction (t = 8.499, 23.782, P <0.01). The correct rate of double task reaction was significantly lower than that of the control group (t = 13.749, P <0.01). CONCLUSIONS: CAPN patients have already had advanced mental disorders of the brain before the clinical manifestations of the CNS appear, and cognitive psychology tests are helpful for their early diagnosis.