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前列腺素E_1(PGE_1)对胶原病的疗效如何虽尚未弄清,但对于胶原病并发末梢血管障碍 (即溃疡,各种四肢感觉异常以及多发性神经炎等)的疗效显著。市售PGE_1虽有出现副作用和疗效较弱等缺点,但由于可良好地控制上述胶原病的并发症状而受到人们注意。作者的研究表明,装入脂肪微粒中的脂PGE_1,无刺激性,在肺内失活较少、并有选择地移向病变部位的特点,其作用明显优于PGE_1。作者进行了下述对比实验。即给予伴有末梢血管障碍、糖尿病性神经症、慢性动脉闭锁症的胶原病患者分别使用脂PGE(3～10μg)和
Although the effect of prostaglandin E_1 (PGE_1) on collagen disease has not yet been clarified, it has a significant effect on collagen-related peripheral vascular disorders (ie, ulcers, abnormal sensations in all extremities, polyneuritis, etc.). Although commercially available PGE_1 has the drawbacks of side effects and weaker therapeutic effects, attention is paid to the fact that PGE_1 can control the above-mentioned complications of collagen disease well. Authors’ studies have shown that lipid PGE 1 loaded into fat particles is non-irritating, less inactivated in the lung, and selectively migrates to the lesion site, and its effect is significantly better than that of PGE 1. The author conducted the following comparative experiment. That is, patients with collagen disease accompanied by peripheral vascular disorders, diabetic neurosis and chronic atherosclerosis were treated with lipopolysaccharide (PGE) (3 to 10 μg) and