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目的:检测人S100钙结合蛋白A9(S100A9)蛋白在口腔鳞状细胞癌(OSCC)组织中的表达,分析其与OSCC临床特征及病理情况的关系,并探讨其在OSCC的早期诊断及预后中的意义。方法:采用免疫组织化学SP法、Western blot检测口腔正常组织标本30例及OSCC标本35例中的S100A9蛋白表达情况。结果:OSCC瘤体组织中S100A9显示为高表达(阳性率77.1%),明显高于正常组织组(阳性率46.7%),二者比较差异有统计学意义(P<0.05);其中中低分化组的表达高于高分化组,Ⅲ~Ⅳ期OSCC组的表达高于Ⅰ~Ⅱ期,以上差异均有统计学意义(P<0.05);S100A9蛋白的表达与患者年龄、性别无关(P>0.05)。结论:S100A9高表达可能在OSCC的发展中发挥十分重要的作用,其表达很可能成为OSCC诊断和预后的分子指标。
OBJECTIVE: To detect the expression of S100A9 (S100A9) protein in oral squamous cell carcinoma (OSCC) and to analyze its relationship with the clinical characteristics and pathological status of OSCC and to explore its relationship with early diagnosis and prognosis of OSCC Meaning. Methods: Immunohistochemical SP method and Western blot were used to detect the expression of S100A9 protein in 30 oral normal tissues and 35 OSCC specimens. Results: The expression of S100A9 in OSCC was high (77.1% positive), which was significantly higher than that in normal tissue (46.7% positive), the difference was statistically significant (P <0.05) (P <0.05). The expression of S100A9 was not related to the age and sex of the patients (P> 0.05). Conclusion: The high expression of S100A9 may play a very important role in the development of OSCC. The expression of S100A9 may be a molecular marker for the diagnosis and prognosis of OSCC.