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环六亚甲基二乙酰胺诱导蛋白(hexamethylene bis-acetamide-inducible protein,HEXIM)是新近发现的参与转录延伸调控的蛋白质,包括HEXIM1和HEXIM2两种同源物.两者均为dsRNA结合蛋白,常以二聚体形式存在,且在调控真核生物RNA聚合酶Ⅱ所催化的转录延伸中功能互补.HEXIM主要通过与7SK snRNA结合,再与正性转录延伸因子b(positive transcription elongation factor b,P-TEFb)形成复合物,抑制P-TEFb的激酶活性,进而抑制转录延伸.近年来发现,HEXIM的转录延伸调控作用参与了人类AIDS、心肌肥大、恶性肿瘤等多种疾病的发生、发展过程.开展以HEXIM为分子靶标的新药研发将为相关疾病的治疗开辟新的途径.
Hexamethylene bis-acetamide-inducible protein (hexamethylene bis-acetamide-inducible protein, HEXIM) is a recently discovered protein involved in transcription elongation regulation, including two homologues of HEXIM1 and HEXIM2, both of which are dsRNA binding proteins, Often exists in the form of dimer and is functionally complementary to transcriptional elongation catalyzed by RNA polymerase II.HEXIM binds to 7SK snRNA and then interacts with positive transcription elongation factor b P-TEFb) to inhibit the kinase activity of P-TEFb, thereby inhibiting the transcriptional elongation.In recent years, it has been found that the transcriptional elongation regulation of HEXIM is involved in the occurrence and development of various diseases such as human AIDS, cardiac hypertrophy and malignant tumors The development of new drugs targeting HEXIM as a molecular target will open up new avenues for the treatment of related diseases.