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A series of bis-quaternary ammonium compounds(bis-QACs) N,N’-hevamethylenebis(1-alkyl-4-carbamoyl pyridinium bromide)(4BCAP-6,n)(alkyl chain length,n=8,10,12,14,16 and 18) were synthesized and characterized.Their surface tensions,critical micelle concentrations(CMC),and antimicrobial activities were evaluated.4BCAP-6,10 exhibited the strongest antimicrobial activities except for that against Proteus vulgari.The activities of 4BCAP-6.n against Escherichia coli zk126 were not significantly influenced by temperature.pH and initial bacteria concentration.These results indicate that bis-QACs exhibit high antimicrobial activity regardless of the environmental conditions.
A series of bis-quaternary ammonium compounds (bis-QACs) N, N’-hevamethylenebis (4BCAP-6, n) 14,16 and 18) were synthesized and characterized. Their surface tensions, critical micelle concentrations (CMC), and antimicrobial activities were as.4 BCAP-6,10 exhibited the strongest antimicrobial activities except for that against Proteus vulgari. Activities 4BCAP- 6.n against Escherichia coli zk126 were not significantly influenced by temperature. PH and initial bacteria concentration. The results show that bis-QACs exhibit high antimicrobial activity regardless of the environmental conditions.