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血管紧张素原(AGT)主要在肝脏合成,是肾素-血管紧张素系统的惟一初始底物。AGT基因核心启动子区域位于TATA框与转录起始位点之间,对AGT基因转录表达起重要调空作用。AGT基因转录起始位点上游(-6)位点存在A～G突变,该突变可以直接影响AGT基因基础转录速率。研
Angiotensinogen (AGT) is synthesized mainly in the liver and is the only initial substrate for the renin-angiotensin system. AGT gene core promoter region is located between the TATA box and the transcriptional start site, plays an important role in AGT gene transcription and modulation. There is A ~ G mutation in the upstream (-6) site of AGT gene transcription initiation site, which can directly affect basic transcription rate of AGT gene. research