目的:研究唐氏综合征患者相对于其他患病的危险性,以及患癌症和选择性免疫相关性疾病的危险性。设计:对医院的病例摘要和死亡记录进行队列分析。结果用唐氏综合征和非唐氏综合征患者的疾病发生率的比率来表示。机构:1963-1999年英格兰以前的牛津健康地区。研究对象:1453例唐氏综合征患者和用做比较的460000例其他疾病患者。主要结果:如预期所料,唐氏 PURPOSE: To investigate the risk of Down Syndrome patients relative to other illnesses and the risk of cancer and selective immune-related diseases. Design: Cohort analysis of hospital summary and death records. The results are expressed as a ratio of the incidence of disease in Down’s syndrome and non-Down Syndrome patients. Institution: 1963-1999 former Oxford health area in England. Subjects: 1453 Down Syndrome patients and 460,000 other disease patients to be compared. Main result: As expected, Down