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从2003年8月~2005年12月因骨关节疼痛在四川大学华西医院康复科就诊的男性患者中,选取40岁以上且无腰椎骨质增生,T值<-1者为研究对象,共566例,年龄40~93岁,平均62.93±13.50岁。测定L2-4正位骨密度,记录其年龄、身高、体重、糖尿病患病情况、运动和吸烟习惯等基线资料,并计算体重指数。按T值大小分骨量减少组和骨质疏松组。结果显示:两组基线资料中,BMI及运动状况比较,差异有统计学意义(P<0.05),骨质疏松组的BMI大于骨量减少组,但参加运动者较少;多元线性回归分析表明:BMI每增加1 kg/m2,腰椎平均BMD将下降0.003 g/cm2(P=0.002);年龄与腰椎平均BMD呈负相关(B=-0.001,P=0.035);参加运动情况为正相关(P=0.000);而吸烟情况对腰椎平均BMD的影响无统计学意义(P=0.837)。提示BMI增加,即脂肪含量增加,会引起骨量减少及骨质疏松患者腰椎平均BMD的下降。有研究报道只有通过增加肌肉含量提高BMI者,才能预防骨质疏松,因此我们认为日后研究BMI与BMD相关性时,需考虑研究对象的肌肉含量。
From August 2003 to December 2005, a total of 566 male patients aged 40 years and older who had no lumbar hyperosteogeny and T value <-1 were enrolled in the study of patients with bone and joint pain in the rehabilitation department of West China Hospital of Sichuan University from August 2003 to December 2005. Cases, aged 40 to 93 years, mean 62.93 ± 13.50 years. L2-4 positive bone mineral density was measured and baseline data such as age, height, weight, prevalence of diabetes, exercise and smoking habits were recorded, and body mass index was calculated. According to the value of T value osteopenia group and osteoporosis group. The results showed that BMI and exercise status were significantly different between the two groups (P <0.05). BMI in osteoporosis group was higher than that in osteopenia group, but there was less participation in exercise. Multivariate linear regression analysis (P = 0.002). The mean BMD of lumbar spine was negatively correlated with age (B = -0.001, P = 0.035). Participation in exercise was positively correlated with P = 0.000). However, smoking had no effect on average BMD of lumbar spine (P = 0.837). Tip BMI increased, that is, increased fat content, can cause osteopenia and osteoporosis in patients with average lumbar BMD decline. It has been reported that osteoporosis can be prevented only by increasing BMI by increasing muscle mass. Therefore, we consider that muscle mass should be considered in future studies on the correlation between BMI and BMD.