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皮肤、皮下组织和内脏器官的血管周围浸润是早期系统性硬皮病(SSc)的特征。为进一步了解外周血单个核细胞(PBMC)和血管内皮间相互作用的变化在 SSc 发展中所起的作用及各种细胞因子对 PBMC 与内皮细胞(EC)粘附的影响,作者研究了61例各型硬皮病[肢端性硬皮病、弥散性硬皮病和过渡型(肢端性-系统性硬皮病)]患者 PBMC 由血管壁迁移至血管外即 PBMC 对 EC 的粘附作用,并以38例正常人作为对照进行比较。
Perivascular infiltrates of the skin, subcutaneous tissue and internal organs are characteristic of early systemic scleroderma (SSc). In order to further understand the role of changes in the interaction between peripheral blood mononuclear cells (PBMCs) and vascular endothelium in the development of SSc and the effects of various cytokines on the adhesion of PBMCs to endothelial cells (ECs), we studied 61 patients PBMC migration from the vascular wall to extravascular, PBMC-to-EC adhesion in various types of scleroderma [acral scleroderma, diffuse scleroderma and transitional (acral-systemic scleroderma) , And 38 normal people as a control for comparison.