随着血小板生理和生化研究的进展,及更敏感的血小板功能试验的建立,遂将尿毒症出血的原因归之于血小板质的缺陷。1956年最先发现患尿毒症有出血倾向的病人通常有凝血酶原消耗异常。此后反复证实与血小板3因子缺陷有关。而血小板粘附和聚集亦有 With the progress of physiological and biochemical studies of platelets and the establishment of more sensitive platelet function tests, the cause of uremic hemorrhage is attributed to platelet defects. In 1956, patients with bleeding tendency who first found uremia usually had abnormal prothrombin consumption. Since then repeatedly confirmed with platelet 3 factor deficiencies. The platelet adhesion and aggregation also