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以大鼠脑血栓形成为模型,观察槲皮素磷酯钾对大鼠脑血栓形成术24h后血小板聚集、血浆TxB2和6-keto-PGF12水平的影响,以及脑电图、脑重量和病理组织学改变。结果表明:复合血栓诱导剂1ml kg-1经颈内动脉注射能诱发大鼠同侧大脑半球内血栓形成,槲皮素磷酯酶钾10-20 mg kg-1能对抗大鼠脑血栓形成,降低体内血小板自发性聚集,抑制血浆TxB2的升高。提示槲皮素磷酸酯钾可能通过其抗血小板聚集及影响花生回烯酸代谢而发挥抗脑血栓形成作用。
Rat cerebral thrombosis was used as a model to observe the effect of quercetin potassium phosphate on platelet aggregation, plasma TxB2 and 6-keto-PGF12 levels after cerebral thrombosis in rats 24h, and EEG, brain weight and pathological tissue Learning to change. The results showed that the thrombosis of ipsilateral hemisphere could be induced by injection of 1 ml kg-1 compound thrombosis in the internal carotid artery. Potassium 10-20 mg kg-1 of quercetin phosphates could antagonize cerebral thrombosis in rats, Reduce the spontaneous platelet aggregation in vivo, inhibit the increase of plasma TxB2. Tip quercetin potassium phosphate may play an anti-cerebral thrombosis role through its anti-platelet aggregation and affect peanut acid metabolism.