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目的 探讨孕早中期母体血清促甲状腺激素对母婴结局的影响.方法 将1 364例孕早中期女性根据血清促甲状腺激素水平分为A、B、C3组,C组给予左旋甲状腺素治疗.比较3组孕妇的不良妊娠结局和新生儿不良结局.结果 B组低体质量儿及宫内生长受限发生率显著高于A组及C组(P＜0.05),A组与C组比较差异无统计学意义(P＞0.05).B组妊娠期糖代谢异常、胎膜早破及早产发生率显著高于A组及C组(P＜0.05),A组与C组比较差异无统计学意义(P＞0.05).不良妊娠结局组血清促甲状腺激素水平2.5 mIU· L -1-5.17 mlU · L-1者显著多于无不良妊娠结局组(P＜0.01).结论 孕早中期母体血清促甲状腺激素水平升高会增大母婴不良结局概率,可给予左旋甲状腺素治疗.“,”Objective To investigate the effect of maternal serum TSH on maternal and infant outcome in early pregnant women. Method A total of 1364 pregnant women with early pregnancy were divided into group A, B,C. Group C was given levothyrocine treatment. Compare the adverse pregnancy outcomes and adverse neonatal outcomes of the three groups. Results The occurrence rates of low weight infant and intrauterine growth restriction in group B were significantly higher than those in group A (P＜0.05),the difference between group A,C had no statistic significance (P＞0.05). The occurrence rates of GIGT, PROM, premature delivery in group B were significantly higher than those in group A, C (P＜0.05),the difference between group A, C had no statistic significance (P＞0.05). Serum TSH level in the adverse pregnancy outcomes group (2.5 mIU · L-1-5.17 mIU ·L-1) was significantly higher than that in the non adverse pregnancy outcomes group (P＜0.01). Conclusions The elevated maternal serum TSH levels in early pregnant women may increase the incidence of maternal and child adverse outcomes. L-thyroxine can be used to reduce the incidence.